Many nutritional approaches such as dietary supplements have been studied for menopause symptoms. However, none has clearly been shown to be helpful. There’s little information on the long-term safety of dietary supplements, and some can have harmful side effects or interact with drugs. The sections below give more detail about several dietary supplements studied for menopause symptoms.
Phytoestrogens
- Phytoestrogens are substances from plants that have chemical structures similar to those of the female hormone estrogen. The isoflavones found in soy and red clover are examples of phytoestrogens. Flaxseed is another phytoestrogen source.
- Studies that tested isoflavones from soy or red clover for their ability to relieve menopause symptoms have had inconsistent results. Studies of flaxseed products found them to be no more effective than a placebo (an inactive substance) in reducing hot flashes.
- Phytoestrogens appear to be safe for short-term use, but their long-term safety hasn’t been established. Because phytoestrogen supplements may have effects like those of the hormone estrogen, they may not be safe for women who shouldn’t take estrogen.
Black Cohosh
- Black cohosh is an herb native to North America. The roots and rhizomes (underground stems) of the plant are used in dietary supplements.
- Studies that tested black cohosh for menopause symptoms have had inconsistent results. A 2012 research review concluded that there’s not enough evidence to support its use for menopause symptoms.
- Black cohosh generally has only mild side effects, if any. However, rare cases of liver damage—some of them very serious—have been reported in people taking commercial black cohosh products. It’s uncertain whether black cohosh was responsible for the liver damage. Nevertheless, people with liver disorders should consult a health care provider before taking black cohosh products. Anyone who develops symptoms of liver trouble, such as abdominal pain, dark urine, or jaundice, while taking black cohosh should stop using it and consult a health care provider.
DHEA
- Dehydroepiandrosterone (DHEA) is a substance that’s naturally made in the body, where it’s converted into the hormones testosterone and estrogen. DHEA production decreases as people grow older, but the significance of this change, including whether it affects aging and menopause symptoms, is unclear.
- It’s uncertain whether DHEA is useful in treating menopause symptoms.
- The long-term safety of taking DHEA supplements is unknown. Some evidence suggests that even short-term use of these supplements may have harmful effects, including liver damage.
Dong Quai
- In traditional Chinese medicine, the herb dong quai is often used for women’s health problems, including menopause. However, very little research has been done on dong quai for menopausal symptoms, so no conclusions can be reached about its effects.
- Dong quai may interact with the anticoagulant (blood-thinning) drug warfarin (Coumadin).
Vitamin E
- A few studies have suggested that vitamin E supplements might be helpful for menopause symptoms. However, the amount of research is small, and the effect is also small. For example, in one study, women taking vitamin E averaged one fewer hot flash per day.
- Vitamin E, in the high doses found in supplements, may increase the risk of bleeding (including strokes due to bleeding in the brain) and interact with anticoagulant (blood-thinning) medications such as warfarin (Coumadin).
Other Dietary Supplements
Other dietary supplements that have been studied for menopause symptoms include evening primrose oil, ginseng, kava, melatonin, and wild yam. However, very little research has been done on these products for menopausal symptoms, so no conclusions can be reached about their effectiveness. Kava supplements have been linked to a risk of severe liver disease.