Argon plasma coagulation (APC) is a medical procedure that applies ionized gas and an electrical current to your digestive tract. It’s performed during a colonoscopy or upper endoscopy to seal bleeding, reduce tumors or stop weight gain after weight loss surgery.

Argon plasma coagulation (APC), also called argon photocoagulation, is a medical procedure performed during a bronchoscopy, colonoscopy or upper endoscopy. Providers use it to treat a variety of conditions in your gastrointestinal system or lungs and airways.

APC uses ionized gas and an electrical current to create blood clots or scars, which can help by stopping internal bleeding or removing growths. It’s a minimally invasive method to access your organs without incisions (cuts).

Your healthcare provider may recommend APC to:

  • Address weight gain after weight loss (to tighten an area that has stretched out).
  • Reduce the size of a tumor if you can’t have more extensive surgery.
  • Remove polyps.
  • Stop or seal internal bleeding from lesions along your digestive tract, like rectal bleeding or gastric antral vascular ectasia syndrome (known as watermelon stomach).
  • Treat Barrett’s esophagus or conditions in your lungs or airway.

A gastroenterologist — a physician specializing in the digestive system — usually performs an APC on the digestive tract. A pulmonologist — a physician specializing in the lungs and airway — also may perform the procedure.

APC is a specific type of ablation therapy. It uses a form of heat to destroy abnormal tissues.

Preparation for argon plasma coagulation depends on whether you have it during:

  • Bronchoscopy, which accesses your lungs through your nose or mouth.
  • Colonoscopy, which examines the inside of your large intestine (colon).
  • Upper endoscopy and double balloon enteroscopy, which examine your esophagus, stomach and small intestine.

Your healthcare team may ask you to avoid eating or drinking for several hours before the procedure. Or they may prescribe bowel preparation to clear out your digestive system beforehand. They also may ask you to temporarily stop taking certain medications, like aspirin and blood thinners.

Your physician may recommend anesthesia to keep you comfortable during APC. This requires inserting a thin tube in your vein (called an intravenous line or IV).

Then, your gastroenterologist will:

  1. Have you lie down on a treatment table or bed.
  2. Insert a thin, flexible scope into your body via your mouth or nose (upper endoscopy or bronchoscopy) or your anus (colonoscopy). The scope has a tiny light and camera at the end to guide the procedure.
  3. Place a grounding pad near your body to protect you from the electrical current.
  4. Use a catheter to insert an argon plasma coagulation device through the scope and thread it to the appropriate place inside your body.
  5. Release argon gas through the catheter and then ignite it using the electrical current.
  6. Adjust the position of the catheter and the levels of argon gas and electrical current, as needed.
  7. Remove the scope, catheter and grounding pad when finished.

Argon plasma coagulation usually takes 15 minutes to an hour.

After the procedure, you’ll stay in a recovery room as you wake up from anesthesia. You may experience some side effects, including:

  • Bloated stomach.
  • Gas and gas pain.
  • Lightheadedness or fatigue.

Your healthcare team will use anesthesia so you don’t feel pain during the procedure.

APC has several potential benefits, including:

  • Destroying or sealing tissue that’s bleeding.
  • Eliminating abnormal tissue, whether noncancerous, precancerous or cancerous.
  • Revising or correcting weight loss surgery so you stop gaining weight.

APC is generally safe. Complications are rare, but may include:

  • Bleeding.
  • Complications from anesthesia (for example, problems waking up, trouble breathing or heart issues).
  • Stenosis (narrowing) of digestive structures.
  • Torn tissue in your esophagus, stomach or intestines.

Most people can return home immediately after APC and resume normal activities the next day. Your doctor may recommend some limitations for a few hours or days, such as:

  • Avoid drinking alcohol.
  • Don’t drive or operate heavy machinery because of the effects of sedation/anesthesia.
  • Have someone drive you home and stay with you for a few hours.
  • Your provider will advise you about your diet after argon plasma coagulation. You should be able to restart your usual diet slowly.

When should I see my healthcare provider?

Complications after APC are rare, but seek medical attention if you experience:

  • Abdominal pain that’s severe and doesn’t get better when you pass gas.
  • Chest pain.
  • Dizziness.
  • Fever or chills.
  • Trouble swallowing or pain in your throat that gets worse over time.
  • Rectal bleeding, which may look red or black on toilet paper or in poop.
  • Shortness of breath.
  • Vomiting blood, which may look red or like coffee grounds.
  • Electrocautery and Argon Plasma Coagulation (https://journal.chestnet.org/article/S0012-3692(15)33714-4/fulltext)Chest. 2003;123(5):P1704-1705. Accessed 12/11/2023.
  • National Institute of Diabetes and Digestive and Kidney Diseases. Colonoscopy (https://www.niddk.nih.gov/health-information/diagnostic-tests/colonoscopy). Accessed 12/11/2023.
  • National Institute of Diabetes and Digestive and Kidney Diseases. Upper GI Endoscopy (https://www.niddk.nih.gov/health-information/diagnostic-tests/upper-gi-endoscopy#:~:text=If%20you%20have%20any%20of,throat%20pain%20that%20gets%20worse). Accessed 12/11/2023.
  • Sagawa T, Takayama T, Oku T, et al. Argon plasma coagulation for successful treatment of early gastric cancer with intramucosal invasion (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1773547/)Gut. 2003;52(3):334-339. Accessed 12/11/2023.
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