Mesenteric Lymphadenitis
Lymphadenitis is a condition in which the small round or bean-shaped clusters of cells, called lymph nodes, become swollen and inflamed. The swelling can affect the lymph nodes in the membrane that connects the bowel to the wall around the stomach area, called the mesentery. Then the condition is called mesenteric lymphadenitis.
An infection in the intestines, such as a virus, is the usual cause of mesenteric lymphadenitis. Also called mesenteric adenitis, the condition mainly affects children and teens.
Mesenteric lymphadenitis can act like appendicitis or a condition in which part of the intestine slides into another part of the intestine, called intussusception. Unlike appendicitis or intussusception, mesenteric lymphadenitis usually clears up on its own.
Possible symptoms of mesenteric lymphadenitis include:
- Pain in the stomach area, often on the lower right side, but the pain can be more spread out.
- General tenderness of the stomach area.
- Fever.
- Enlarged mesenteric lymph nodes.
Depending on what’s causing the condition, symptoms also might include:
- Diarrhea.
- Nausea and vomiting.
When to see a doctor
Pain in the stomach area is common in children and teens. So it can be hard to know when to seek medical advice.
Call a healthcare professional right away for a child who has:
- Sudden, severe pain in the stomach area.
- Stomach area pain with fever.
- Stomach area pain with diarrhea or vomiting.
- Tenderness to touch of the stomach area.
- Bloody or maroon-colored stool.
Also, call a healthcare provider for a child who has pain in the stomach area that doesn’t get better in a short time and who also:
- Has a change in bowel habits.
- Has a loss of appetite.
- Is not able to sleep.
The most common cause of mesenteric lymphadenitis is a viral infection, such as gastroenteritis. Gastroenteritis is often called stomach flu. This infection causes inflammation and swelling in the lymph nodes in the thin tissue that attaches the intestine to the back of the wall around the stomach area, called mesentery.
Other causes of mesenteric lymphadenitis include bacterial infection, inflammatory bowel disease and lymphoma.
Any infection that causes inflammation and swelling in the lymph nodes in the tissue that attaches the bowel to the abdominal wall increases the risk of mesenteric lymphadenitis.
Conditions that raise the risk of mesenteric lymphadenitis include:
- Viral or bacterial gastroenteritis.
- Inflammatory bowel disease.
- Lymphoma.
Diagnosing mesenteric lymphadenitis involves taking a medical history and doing an exam. Tests might include:
- Blood tests. Certain blood tests can help show if there’s an infection and what type of infection it is.
- Imaging studies. An ultrasound of the stomach area is often used to diagnose mesenteric lymphadenitis. A CT scan of the stomach area also might be used.
Mild cases of mesenteric lymphadenitis and those caused by a virus usually go away on their own. Full recovery can take four weeks or more.
For treatment of fever or pain, consider giving your child infants’ or children’s over-the-counter fever and pain medications such as acetaminophen (Tylenol, others) or ibuprofen (Advil, Motrin, others). They’re safer than aspirin.
Use caution when giving aspirin to children or teenagers. Though aspirin is approved for use in children older than age 3, children and teenagers recovering from chickenpox or flu-like symptoms should never take aspirin. This is because aspirin has been linked to Reye’s syndrome, a rare but potentially life-threatening condition, in such children.
Antibiotics might be prescribed for a moderate to severe bacterial infection.
References
- Nauman MI. Causes of acute abdominal pain in children and adolescents. https://www.uptodate.com/contents/search. Accessed March 8, 2023.
- Ferri FF. Mesenteric adenitis. In: Ferri’s Clinical Advisor 2023. Elsevier; 2023. https://www.clinicalkey.com. Accessed March 8, 2023.
- Mesenteric adenitis. Radiopaedia.org. https://radiopaedia.org/articles/mesenteric-adenitis?lang=us. Accessed March 8, 2023.
- Ozdamar MY, et al. Acute mesenteric lymphadenitis in children: Findings related to differential diagnosis and hospitalization. Archives of Medical Science. 2020; doi:10.5114/aoms.2018.79430.
- AAP Committee on Infectious Diseases. Recommendations for prevention and control of influenza in children, 2022-2023. Pediatrics. 2022; doi:10.1542/peds.2022-059274.
- Sullivan JE, et al. Fever and antipyretic use in children. Pediatrics. 2011; doi:10.1542/peds.2010-3852. Reaffirmed October 2022.
- Labeling of drug preparations containing salicylates. Electronic Code of Federal Regulations. https://www.ecfr.gov/current/title-21/chapter-I/subchapter-C/part-201/subpart-G/section-201.314. Accessed Jan. 26, 2023.
- Medical review (expert opinion). Mayo Clinic. Jan. 25, 2023.
- Medical review (expert opinion). Mayo Clinic. March 9, 2023.
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