Learn about Peritonitis, a serious inflammation of the abdominal lining often caused by infection. Discover symptoms, causes, diagnosis, emergency treatment options, and potential complications with Curafile’s expert guide.
Peritonitis
One common and serious symptom is a dull ache in your belly that suddenly becomes a sharp pain and doesn’t let up. The pain can be so intense that you can’t sit still. If that’s your situation, call 911 (or your local emergency service number) or have someone take you to the emergency room.
Other peritonitis symptoms may include:
- Constipation and other symptoms of paralytic ileus (temporary paralysis of your intestines)
- Deep, rapid breathing, dry tongue and lips, and other symptoms of dehydration
- Edema (swelling)
- Fatigue
- Fast heart rate
- Fever
- Swollen belly that’s tight and tender to the touch.
Bacterial infections are the most common cause of peritonitis. Some start in your peritoneum (primary infections). But most happen when a bacterial infection in a nearby organ spreads to your peritoneum. Healthcare providers call these secondary infections.
You may also develop peritonitis if fluid from nearby organs leaks into your peritoneum (bowel perforation). The fluid causes inflammation. Providers may call this chemical peritonitis.
Secondary infections
These infections happen when you have a condition that damages organs close to your peritoneum. Your damaged organs may release infected fluid that seeps into your peritoneum. This can happen if you have:
- Appendicitis that involves a burst appendix
- Diverticulitis or inflammatory bowel disease that causes holes in your gastrointestinal tract
- Fallopian tube rupture (ruptured ectopic pregnancy)
- Pelvic inflammatory disease involving a tubo-ovarian abscess that ruptures
- Peptic ulcer disease that makes a hole in your stomach
- Surgical site infection from abdominal surgery
- Traumatic injury to your belly that lets bacteria get into it
Primary infections
Primary infections start in your peritoneum. They usually happen in one of two ways:
- You have ascites (fluid buildup) in your peritoneum. Cancer in your belly, cirrhosis or congestive heart failure can cause ascites. Healthcare providers may call this spontaneous bacterial peritonitis (SPB).
- You need medical treatment that can let bacteria into your peritoneal cavity. This can happen if you need peritoneal dialysis. Bacteria may also get into it if you’re receiving nutrition through a feeding tube (tube feeding).
Chemical peritonitis
There are fluids in your body that are harmless when they stay where they belong. But they can cause inflammation if they end up in your peritoneum. This can happen if you have conditions like:
- Pancreatitis that makes a hole in your pancreas: Pancreatic enzymes flow through the hole into your peritoneum to cause inflammation.
- Severe cholecystitis that causes a hole in your gallbladder: The hole lets bile leak into your peritoneum.
- Stomach ulcers that wear through the wall of your stomach: This allows stomach acid to get to your peritoneum.
The most common and most serious complications are septicemia and sepsis. These conditions are life-threatening medical emergencies. Other potential complications are:
- Dehydration and electrolyte imbalance
- Hepatorenal syndrome
- Paralytic ileus
- Scar tissue (abdominal adhesions) that causes bowel obstruction
- Tertiary peritonitis, an infection that comes back after treatment
A healthcare provider will ask about your symptoms. They’ll also ask if you’re receiving treatment for any medical conditions. They’ll do a physical exam that focuses on your belly. They’ll check to see if your belly is extremely tender to their touch or is swollen and tight
Your provider may do blood tests that detect inflammation and infection. For example, they may check for leukocytosis (high white blood cell count). A high white blood cell count is a sign that your body is fighting infection or inflammation. They may do other tests like:
- CT scan, MRI or abdominal ultrasound to look for changes in organs inside your belly
- Paracentesis to get a sample of fluid from your peritoneum
- Laparoscopy, a procedure that lets providers look at the inside of your belly
How is peritonitis treated?
Treatment starts with IV fluids and broad-spectrum antibiotics. IV fluids reduce your risk of shock. They help restore the balance of fluids in your body. Broad-spectrum antibiotics are the first line of defense against the infection in your peritoneum.
Your healthcare providers may do more blood tests. They’ll identify the bacterium or pathogen causing the infection. You may receive a different antibiotic that targets the specific bacterium or pathogen.
Your providers’ priority is preventing sepsis or septicemia. Next, they’ll focus on the specific bacterium or pathogen that triggered the infection. They’ll also treat the condition that led to bacteria ending up in your peritoneum.
Recovery time
Recovery time varies. You may recover from peritonitis within a few weeks if you receive treatment early on. But peritonitis often happens because you have an underlying condition. Recovering from that condition may take much longer.
When should I seek care?
Go to the emergency room or call 911 (or your local emergency services number) if you have sudden, severe belly pain. You may not have peritonitis. But belly pain that comes on fast (acute abdomen) is a medical emergency.
References
- Brown D, Vashisht R, Caballero Alvarado JA. Septic Peritonitis (https://www.ncbi.nlm.nih.gov/books/NBK526129/#:~:text=Sepsis%20is%20a%20pro%2D%20and,interval%20before%20initiation%20of%20treatment.&text=When%20an%20infection%20in%20the,Severe%20Septic%20Peritonitis). Updated 9/19/2022. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan. Accessed 7/29/2025..
- Bush LM, Levison ME. Peritonitis and intraperitoneal abscesses. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 74. Accessed 7/29/2025.
- Merck Manual, Consumer Version. Acute abdominal pain (https://www.merckmanuals.com/home/digestive-disorders/gastrointestinal-emergencies/acute-abdominal-pain?query=peritonitis). Updated 7/2024. Accessed 7/29/2025.
- Napolitano LM. Intra-abdominal Infections (https://pubmed.ncbi.nlm.nih.gov/35172355/). Semin Respir Crit Care Med. 2022 Feb;43(1):10-27. Accessed 7/25/2025.
- National Health Service (UK) Peritonitis (https://www.nhs.uk/conditions/peritonitis/). Updated 8/1/2023. Accessed 7/29/2025.
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