Pyoderma gangrenosum (pie-o-DUR-muh gang-ruh-NO-sum) is a rare condition that causes large, painful sores on the skin. The sores can develop quickly. Most often they appear on the legs.
The exact causes of pyoderma gangrenosum are unknown, but it appears to be a disorder of the immune system. People who have certain other conditions are at higher risk of pyoderma gangrenosum.
The condition usually clears up with treatment. But the sores often leave scars and can show up in new spots.
Pyoderma gangrenosum usually starts with a small bump on the skin. It might look like a spider bite. Within days it can turn into a large and painful open sore.
The sore usually appears on the legs but may develop anywhere on the body. Sometimes it appears around surgical sites. If you have two or more sores, they may grow and merge into one.
Talk with a healthcare professional if you develop a painful, rapidly growing skin wound.
No one knows the exact cause of pyoderma gangrenosum. It’s often seen in people who have autoimmune diseases, such as ulcerative colitis, Crohn’s disease and arthritis. And some studies suggest that it may be passed down through families.
If you have pyoderma gangrenosum, getting a cut or other skin wound can bring on new sores. The condition isn’t an infection and it isn’t contagious.
Certain factors may increase your risk of pyoderma gangrenosum, including:
Possible complications of pyoderma gangrenosum include infection, uncontrolled pain, scarring and and changes in skin color after the affected skin heals. This change in skin color is called postinflammatory hyperpigmentation when the skin darkens and postinflammatory hypopigmentation when the skin loses color. People with brown or Black skin have a higher risk of long-term skin color changes.
You can’t prevent the first instance of pyoderma gangrenosum. If you have the condition, you can help prevent new sores by protecting your skin from injury. Injury or trauma to the skin, including from surgery, can cause new sores to form.
It also may help to control any other condition you have that’s related to pyoderma gangrenosum.
Your healthcare professional will talk with you about your symptoms and medical history and conduct a physical exam. No test can confirm a diagnosis of pyoderma gangrenosum. But you may need tests to rule out other conditions that have similar symptoms. These may include blood tests, a chest X-ray, a colon exam or a skin biopsy. A biopsy is a procedure to remove a sample of tissue for testing in a lab.
Correct and early diagnosis is key to effective treatment. You may be referred to a specialist in skin conditions. This type of doctor is called a dermatologist.
Treatment of pyoderma gangrenosum is aimed at reducing swelling, controlling pain and helping skin sores heal. Medicines are the most common treatment. Treatment also might involve wound care and surgery. Your treatment depends on your health, how many sores you have, how deep they are and how fast they’re growing.
Some people respond well to treatment with a combination of medicine taken by mouth, creams and injections. Sores can take weeks or months to heal, and it’s common for new ones to develop.
In addition to applying medicine to your wounds, a healthcare professional may cover them with a moist nonstick dressing and, perhaps, an elasticized wrap. You may be asked to keep the affected area raised. Follow instructions you receive for wound care.
Because pyoderma gangrenosum can be made worse by cuts to the skin, surgery to remove dead tissue is not usually considered a good treatment option. Trauma to the skin may worsen existing sores or bring on new ones.
If sores are large and aren’t healing, a skin graft may be an option. In this procedure, the surgeon attaches a piece of skin from somewhere else on your body over the open sores.
You’re likely to first see your regular healthcare professional. You may then be referred to a doctor who specializes in skin conditions. This type of doctor is called a dermatologist.
Here’s some information to help you get ready for your appointment.
Before your appointment, make a list of:
Your healthcare professional is likely to ask you a few questions, such as:
Women have unique health issues. And some of the health issues that affect both men and women can affect women differently.
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