Dementia
Dementia describes a group of symptoms affecting memory, thinking and social abilities. The symptoms interfere with a person’s daily life. Dementia isn’t one specific disease. Several diseases can cause dementia.
Memory loss is one of the early symptoms of dementia. But having memory loss alone doesn’t mean you have dementia because memory loss can have different causes.
Alzheimer’s disease is the most common cause of dementia in older adults, but there are other causes. Depending on the cause, some dementia symptoms might be reversible.
Dementia is caused by damage to or loss of nerve cells and their connections in the brain. The symptoms depend on the area of the brain that’s affected. Dementia can affect people differently.
Dementias are often grouped by what they have in common. They may be grouped by the protein or proteins deposited in the brain or by the part of the brain that’s affected. Also, some diseases have symptoms like those of dementia. And some medicines can cause a reaction that includes dementia symptoms. Not getting enough of certain vitamins or minerals also can cause dementia symptoms. When this occurs, dementia symptoms may improve with treatment.
Progressive dementias
Dementias that are progressive get worse over time. Types of dementias that worsen and aren’t reversible include:
Alzheimer’s disease. This is the most common cause of dementia. Not all causes of Alzheimer’s disease are known, but a small percentage are related to changes in three genes. These gene changes can be passed down from a parent to a child. While several genes are probably involved in Alzheimer’s disease, one important gene that increases risk is apolipoprotein E (APOE).
People with Alzheimer’s disease have plaques and tangles in their brains. Plaques are clumps of a protein called beta-amyloid. Tangles are fibrous masses made up of tau protein. It’s thought that these clumps damage healthy brain cells and the fibers connecting them.
Vascular dementia. This type of dementia is caused by damage to the vessels that supply blood to the brain. Blood vessel conditions can cause stroke or affect the brain in other ways, such as by damaging the fibers in the white matter of the brain.
The most common symptoms of vascular dementia include trouble with problem-solving, slowed thinking, and loss of focus and organization. These symptoms tend to be more noticeable than memory loss.
Lewy body dementia. Lewy bodies are balloonlike clumps of protein. They have been found in the brains of people with Lewy body dementia, Alzheimer’s disease and Parkinson’s disease. Lewy body dementia is one of the more common types of dementia.
Common symptoms include acting out dreams in sleep and seeing things that aren’t there, known as visual hallucinations. Symptoms also include problems with focus and attention. Other signs include uncoordinated or slow movement, tremors, and stiffness, known as parkinsonism.
- Frontotemporal dementia. This is a group of diseases characterized by the breakdown of nerve cells and their connections in the frontal and temporal lobes of the brain. These areas are associated with personality, behavior and language. Common symptoms affect behavior, personality, thinking, judgment, language and movement.
- Mixed dementia. Autopsy studies of the brains of people age 80 and older who had dementia indicate that in many, dementia had a combination of causes. People with mixed dementia can have Alzheimer’s disease, vascular dementia and Lewy body dementia. Studies are ongoing to determine how having mixed dementia affects symptoms and treatments.
Other diseases linked to dementia
Dementia also can occur with other diseases.
- Huntington’s disease. Huntington’s disease is caused by a genetic change. The disease causes certain nerve cells in the brain and spinal cord to waste away. Symptoms include a decline in thinking skills. Symptoms usually appear around age 30 or 40.
- Traumatic brain injury, also called TBI. This condition is most often caused by head trauma that happens again and again. Boxers, U.S. football players and soldiers might develop TBI. Dementia symptoms depend on the part of the brain that’s injured. TBI can cause depression, explosiveness, memory loss and changes in speech. TBI also may cause slow movement, tremors and stiffness. Symptoms might not appear until years after the trauma.
- Creutzfeldt-Jakob disease. This rare brain disease usually occurs in people without known risk factors. This condition might be due to deposits of infectious proteins called prions. Symptoms of this fatal condition usually appear after age 60. Creutzfeldt-Jakob disease usually has no known cause but it can be passed down from a parent. It also may be caused by exposure to diseased brain or nervous system tissue, such as from a cornea transplant.
- Parkinson’s disease. Many people with Parkinson’s disease eventually develop dementia symptoms. When this happens, it’s known as Parkinson’s disease dementia.
Dementialike conditions that can be reversed
Some dementialike symptoms can be reversed with treatment. They include:
- Infections and immune disorders. Dementialike symptoms can result from a fever or other side effects of the body’s attempt to fight off an infection. Multiple sclerosis and other conditions caused by the body’s immune system attacking nerve cells also can cause dementia.
- Metabolic or endocrine conditions. People with thyroid conditions and low blood sugar can develop dementialike symptoms or other personality changes. This also is true for people who have too little or too much sodium or calcium or aren’t absorbing enough vitamin B-12.
- Low levels of certain nutrients. Not getting enough of certain vitamins or minerals in your diet can cause dementia symptoms. This includes not getting enough thiamin, also known as vitamin B-1, which is common in people with alcohol use disorder. It also includes not getting enough vitamin B-6, vitamin B-12, copper or vitamin E. Not drinking enough liquids, leading to dehydration, also can cause dementia symptoms.
- Medicine side effects. Side effects of medicines, a reaction to a medicine or an interaction of several medicines can cause dementialike symptoms.
- Subdural bleeding. This is bleeding between the surface of the brain and the covering over the brain that can happen in older adults after a fall. Subdural bleeding can cause symptoms similar to those of dementia.
- Brain tumors. Rarely, dementia can result from damage caused by a brain tumor.
- Normal-pressure hydrocephalus. This condition is caused by a buildup of fluid in the cavities in the brain known as ventricles. It can result in trouble walking, loss of bladder function and memory loss.
Dementia symptoms vary depending on the cause. Common symptoms include:
Cognitive changes
- Memory loss, which is usually noticed by someone else.
- Problems communicating or finding words.
- Trouble with visual and spatial abilities, such as getting lost while driving.
- Problems with reasoning or problem-solving.
- Trouble performing complex tasks.
- Trouble with planning and organizing.
- Poor coordination and control of movements.
- Confusion and disorientation.
Psychological changes
- Personality changes.
- Depression.
- Anxiety.
- Agitation.
- Behavior that doesn’t fit the situation.
- Being suspicious, known as paranoia.
- Seeing things that aren’t there, known as hallucinations.
See a healthcare professional if you or a loved one has trouble with memory or has other dementia symptoms. It’s important to determine the cause. Some medical conditions that cause dementia symptoms can be treated.
Many factors can eventually contribute to dementia. Some factors, such as age, can’t be changed, but you can address other factors to reduce your risk.
Risk factors that can’t be changed
Being aware of these risk factors can help you understand your dementia risk.
- Age. The risk of dementia rises as you age, especially after age 65. However, dementia isn’t a typical part of aging. Dementia also can occur in younger people.
- Family history. Having a family history of dementia puts you at greater risk of developing the condition. However, many people with a family history never develop symptoms, and many people without a family history do. There are tests to determine whether you have certain genetic changes that may increase your risk.
- Down syndrome. By middle age, many people with Down syndrome develop early-onset Alzheimer’s disease.
Risk factors you can change
You might be able to manage the following risk factors for dementia.
- Lifestyle factors. Research has found that people at higher risk of dementia who followed a healthy lifestyle lowered their risk of cognitive decline. They ate a diet that included fish, fruits, vegetables and olive oil. They also exercised, had cognitive training and participated in social activities. While no specific diet is known to reduce dementia risk, research indicates that those who follow a Mediterranean style diet have better cognitive function. A Mediterranean diet focuses on fruits, vegetables, cereals, olive oil, nuts, and fish. The diet includes smaller amounts of dairy and meat.
- Drinking too much alcohol. Drinking large amounts of alcohol has long been known to cause brain changes. Several large studies and reviews have linked alcohol use disorders with an increased risk of dementia, particularly early-onset dementia.
- Cardiovascular risk factors. These include obesity, high blood pressure, high cholesterol and the buildup of fats in the artery walls, known as atherosclerosis. Having high levels of low-density lipoprotein (LDL), in particular, is a risk factor for cognitive decline and dementia. Diabetes and smoking also are cardiovascular risk factors. Having diabetes can increase the risk of dementia, especially if blood sugar isn’t managed well. Smoking might increase the risk of developing dementia and blood vessel disease.
- Hearing loss or vision loss that is not treated. Having hearing loss is associated with a higher risk of dementia. The worse the hearing loss, the higher the risk. Research also suggests that vision loss can raise the risk of dementia, while treating vision loss can lower the risk.
- Depression. Depression in adulthood is a risk factor for dementia, particularly in midlife.
- Air pollution. Studies in animals have indicated that air pollution particulates can speed degeneration of the nervous system. And human studies have found that air pollution exposure — particularly from traffic exhaust and burning wood — is associated with greater dementia risk.
- Head trauma. People who’ve had severe head trauma have a greater risk of Alzheimer’s disease. Several large studies found that the risk of dementia and Alzheimer’s disease increased in people age 50 years or older who had a traumatic brain injury, also called TBI. The risk is higher in people with more-severe and multiple TBIs.
- Sleep conditions. People who have sleep apnea and other sleep disturbances might be at higher risk of getting dementia.
- Low levels of certain vitamins and nutrients. Low levels of vitamin D, vitamin B-6, vitamin B-12 and folate can increase the risk of dementia.
- Medicines that can worsen memory. These include sleep aids or allergy medicines that contain diphenhydramine (Benadryl, Unisom, others). They also include medicines you can get with or without a prescription to treat urinary urgency, such as oxybutynin (Oxytrol). Also limit sedatives. Talk with a healthcare professional about whether any of the medicines you take might make your memory worse.
Dementia can affect many body systems and, therefore, the ability to function. Dementia can lead to:
- Poor nutrition. Many people with dementia eventually reduce or stop eating, affecting their nutrient intake. Ultimately, they may be unable to chew and swallow.
- Pneumonia. Trouble swallowing increases the risk of choking. And food or liquids can enter the lungs, known as aspiration. This can block breathing and cause pneumonia.
- Inability to perform self-care tasks. As dementia gets worse, people have a hard time bathing, dressing, and brushing their hair or teeth. They need help using the toilet and taking medicines as directed.
- Personal safety challenges. Some day-to-day situations can present safety issues for people with dementia. These include driving, cooking, and walking and living alone.
- Death. Coma and death can occur in late-stage dementia. This often happens because of an infection.
To diagnose the cause of dementia, a healthcare professional must recognize the pattern of loss of skills and function and determine what a person is still able to do. More recently, biomarkers have become available to make a more accurate diagnosis of Alzheimer’s disease.
A healthcare professional reviews your medical history and symptoms and conducts a physical exam. Someone who is close to you may be asked about your symptoms as well.
No single test can diagnose dementia. You’ll likely need a number of tests that can help pinpoint the problem.
Cognitive and neuropsychological tests
These tests evaluate your thinking ability. A number of tests measure thinking skills, such as memory, orientation, reasoning and judgment, language skills, and attention.
Neurological evaluation
Movement, balance, senses, reflexes and other areas are evaluated.
Brain scans
- CT or MRI. These scans can check for evidence of stroke, bleeding, tumor or fluid buildup, known as hydrocephalus.
- PET scans. These scans can show patterns of brain activity. They can determine whether amyloid or tau protein, hallmarks of Alzheimer’s disease, have been deposited in the brain.
Laboratory tests
Simple blood tests look for changes that affect brain function, such as too little vitamin B-12 in the body or a thyroid gland that is less active than what is typical. Sometimes spinal fluid is examined for infection, inflammation or markers of some diseases.
Psychiatric exam
A mental health professional can determine whether depression or another mental health condition is a part of your symptoms.
Most types of dementia can’t be cured, but there are ways to manage your symptoms.
Medications
The following medicines are used to temporarily improve dementia symptoms.
Cholinesterase inhibitors. These medicines work by boosting levels of a chemical messenger involved in memory and judgment. They include donepezil (Aricept, Adlarity), rivastigmine (Exelon) and galantamine (Zunveyl).
Although primarily used to treat Alzheimer’s disease, these medicines also might be prescribed for other dementias. They might be prescribed for people with vascular dementia, Parkinson’s disease dementia and Lewy body dementia.
Side effects can include nausea, vomiting and diarrhea. Other possible side effects include slowed heart rate, fainting and trouble with sleep.
- Memantine (Namenda). Memantine works by regulating the activity of glutamate. Glutamate is another chemical messenger involved in brain functions such as learning and memory. Memantine is sometimes prescribed with a cholinesterase inhibitor. A common side effect of memantine is dizziness.
- Other medicines. You might take other medicines to treat symptoms or other conditions. You may need treatment for depression, trouble with sleep, hallucinations, agitation, and slow and stiff movements known as parkinsonism.
Two other medicines approved by the U.S. Food and Drug Administration (FDA) are lecanemab-irmb (Leqembi) and donanemab-azbt (Kisunla). They’re approved for people with mild Alzheimer’s disease and mild cognitive impairment due to Alzheimer’s disease.
Clinical trials found that the medicines slowed declines in thinking and functioning in people with early Alzheimer’s disease. The medicines prevent amyloid plaques in the brain from clumping.
Lecanemab is given as an IV infusion every two weeks for 18 months. Then it can be given every two or four weeks afterward. Side effects include infusion-related reactions such as fever, flu-like symptoms, nausea, vomiting, dizziness, changes in heart rate and shortness of breath.
Donanemab is given as an IV infusion every four weeks. Side effects of the medicine may include flu-like symptoms, nausea, vomiting, headache and changes in blood pressure. Rarely, donanemab can cause a life-threatening allergic reaction and swelling.
Also, people taking lecanemab or donanemab may have swelling in the brain or may get small bleeds in the brain. Rarely, brain swelling can be serious enough to cause seizures and other symptoms. Also in rare instances, bleeding in the brain can cause death. The FDA recommends getting a brain MRI before starting treatment. The FDA also recommends periodic brain MRIs during treatment to look for or check symptoms of brain swelling or bleeding.
People who carry a certain form of a gene known as APOE e4 appear to have a higher risk of these serious complications. The FDA recommends testing for this gene before starting treatment.
If you take a blood thinner or have other risk factors for brain bleeding, talk with your healthcare professional before taking lecanemab or donanemab. Blood-thinning medicines may increase the risk of bleeds in the brain. These medicines include clot-busting medicines given to people with strokelike symptoms.
More research is being done on the potential risks of taking lecanemab and donanemab. Other research is looking at how effective the medicines may be for people at risk of Alzheimer’s disease, including people who have a first-degree relative, such as a parent or sibling, with the disease.
Therapies
Therapies can help improve several dementia symptoms and behavior changes. These treatments may include:
- Occupational therapy. An occupational therapist can show you how to make your home safer and teach coping behaviors. The purpose is to prevent accidents, such as falls. The therapy also helps you manage behavior and prepare you for when the dementia progresses.
- Changes to the environment. Reducing clutter and noise can make it easier for someone with dementia to focus and function. You might need to hide objects that can threaten safety, such as knives and car keys. Monitoring systems can alert you if the person with dementia tries to wander.
- Simpler tasks. Breaking tasks into easier steps and focusing on success, not failure, can be helpful. Structure and routine help reduce confusion in people with dementia.
What can I expect if my child has a learning disability?
Even though children don’t outgrow learning disabilities, they can learn to adapt and improve their skills. Children who receive early diagnoses and interventions are more likely to overcome challenges while maintaining a positive self-image.
They may also build on personal strengths that tend to come with learning disorders. For example, people with dyslexia are often especially creative. Children with learning disabilities can grow to become very productive and successful adults.
What are the complications of learning disabilities?
If your child has an LD, they may experience self-esteem issues or believe they aren’t intelligent. They also have a higher risk of developing mental health conditions like anxiety or depression.
Positive support from caregivers, teachers and friends can help your child overcome these obstacles. But don’t hesitate to reach out to a mental health professional, as well.
How long do learning disabilities last?
Learning disabilities are lifelong. This means that adults have learning disabilities, too. Although children typically receive these diagnoses, some people don’t realize they have a learning disability until they’re adults.
There’s no sure way to prevent dementia, but there are steps you can take that might help. More research is needed, but it might help to do the following:
- Keep your mind active. Mentally stimulating activities might delay the onset of dementia and decrease its effects. Spend time reading, solving puzzles and playing word games.
- Be physically and socially active. Physical activity and social interaction might delay the onset of dementia and reduce its symptoms. Aim for 150 minutes of exercise a week.
- Quit smoking. Some studies have shown that smoking in middle age and beyond might increase the risk of dementia and blood vessel conditions. Quitting smoking might reduce the risk and improve health.
- Get enough vitamins. Some research suggests that people with low levels of vitamin D in their blood are more likely to develop Alzheimer’s disease and other forms of dementia. You can increase your vitamin D levels with certain foods, supplements and sun exposure. More study is needed before an increase in vitamin D intake is recommended for preventing dementia. But it’s a good idea to make sure you get adequate vitamin D. Taking a daily B-complex vitamin and vitamin C also might help.
- Manage cardiovascular risk factors. Treat high blood pressure, high cholesterol and diabetes. Pay attention to your levels of LDL cholesterol and get treatment if the levels are too high. High levels of LDL cholesterol in middle age raise the risk of dementia. Lose weight if you’re overweight. High blood pressure might lead to a higher risk of some types of dementia. More research is needed to determine whether treating high blood pressure may reduce the risk of dementia.
- Take care of your mental health. See your healthcare professional if you have depression or anxiety.
- Maintain a healthy diet. A diet such as the Mediterranean diet might promote health and lower the risk of developing dementia. A Mediterranean diet is rich in fruits, vegetables, whole grains and omega-3 fatty acids, which are commonly found in certain fish and nuts. This type of diet also improves cardiovascular health, which may help lower dementia risk.
- Get good-quality sleep. Practice good sleep hygiene. Talk with a healthcare professional if you snore loudly or have times when you stop breathing or gasp during sleep.
- Treat hearing loss. People with hearing loss have a greater chance of developing a condition related to thinking known as cognitive decline. Early treatment of hearing loss, such as use of hearing aids, might help decrease the risk.
- Get regular eye exams and treat vision loss. Research suggests that not treating vision loss may be associated with a raised risk of dementia.
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